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No distinct dose adjustment advisable when tofacitinib coadministered with strong CYP2C19 inhibitors; minimize tofacitinib dose if coadministered with each reasonable CYP3A4 and potent CYP2C19 inhibitors .Ferraro et al (1997b) examined the in vivo dopamine and GABA levels of the nucleus accumbens in rats supplied modafinil, and so they located that